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The combination is not about speeding up weight loss its about supporting the cellular systems that make healthy, sustainable weight loss feel better while its happening

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doi: 10.1007/s10620-020-06749-7 Berg DR, Colombel JF, Ungaro R, et

For example, the use of oral forms of estrogen can be prothrombotic whereas the use of transdermal hormones does not seem to present with the same complication

For more detail about the 2005 survey, see the Survey Methodology section of that years report